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M9470015.TXT
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1994-07-02
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Document 0015
DOCN M9470015
TI Intestinal permeability in patients infected with the human
immunodeficiency virus.
DT 9409
AU Tepper RE; Simon D; Brandt LJ; Nutovits R; Lee MJ; Division of
Gastroenterology, Bronx Municipal Hospital Center,; New York.
SO Am J Gastroenterol. 1994 Jun;89(6):878-82. Unique Identifier : AIDSLINE
MED/94256460
AB OBJECTIVE: The etiology of acquired immunodeficiency syndrome (AIDS)
enteropathy is unknown. This condition has been associated with
malabsorption and villous atrophy. Other disorders with similar
findings, including celiac disease, are characterized by altered
intestinal permeability. Our objective was to confirm (or reject) our
hypothesis that processes that cause increased permeability may occur in
patients with AIDS, and thus be a cause of idiopathic diarrhea. METHODS:
A lactulose-mannitol differential intestinal permeability test was
performed in healthy controls, asymptomatic human immunodeficiency virus
(HIV)-positive patients, and AIDS patients with and without diarrhea.
RESULTS: Asymptomatic HIV-positive patients lactulose and mannitol
recoveries were no different than healthy control patients. AIDS
patients without diarrhea had lactulose recovery similar to healthy
controls and decreased mannitol recoveries; their mean
lactulose:mannitol ratio was no different from that of controls, and
less than that of AIDS patients with diarrhea. AIDS patients with
diarrhea had increased lactulose recovery and decreased mannitol
recovery; their mean lactulose:mannitol ratio was significantly greater
than the ratios in all the other groups. CONCLUSIONS: Patients with AIDS
and diarrhea have altered intestinal permeability. The decreased
absorption of mannitol suggests that the functional absorptive surface
of the intestine decreases as HIV disease progresses.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PHYSIOPATHOLOGY Adult
AIDS-Related Opportunistic Infections/PHYSIOPATHOLOGY
Diarrhea/COMPLICATIONS/PHYSIOPATHOLOGY Human HIV
Seropositivity/PHYSIOPATHOLOGY Intestines/*PHYSIOPATHOLOGY
Lactulose/METABOLISM Mannitol/METABOLISM Middle Age Permeability
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).